Endocrine Abstracts

Background The combination of primary hyperparathyroidism (PHPT) with anemia was first described in 1931. It remains unclear whether PHPT is the direct cause of anemia, or it develops as a PHPT’s complication. The etiology of anemia in PHPT could be multifactorial, including iron deficiency, renal failure as well as bone marrow fibrosis.Aim To assess the prevalence of anemia in patients with PHPT admitted to the Department of Parathyroid Glands Path...

Rationale: The COVID-19 pandemic has accelerated the development of telemedicine technologies. Today there is evidence of the successful use of telemedicine in various areas of healthcare, particularly in endocrinology. At the same time, there is not enough information for efficient integration of telemedicine into the routine management of patients.Aim: The aim of this work was a clinical and demographic analysis of “doctor-patient” telemedici...

Introduction: The enlarged pituitary gland of pregnancy is susceptible to any compromise to its blood supply. Sheehan’s syndrome (SS) occurs as a result of post-partum pituitary infarction or haemorrhage and usually leads to hypopituitarism. It can be fatal but clinical manifestations may change from one patient to another and symptoms may not occur for many years.Methods: We analysed retrospectively five cases of women with SS aged 26&#150...

Objectives: Aberrances in expression and sequence of miR-146a have a well-established role in pathogenesis of papillary thyroid carcinoma (PTC). The G/C heterozygosity in rs2910164 of miR-146a underlies genetic predisposition to PTC and occurs as a somatic mutation in thyroid tumors. Deleterious function of rs2910164 consists in creation of a new variant of microRNA, resulting from the fact that a single microRNA precursor gives rise to −5p and −3p microRNAs. The S...

Background: In recent years, the role of vitamin D in improving the profile of inflammatory markers in order to prevent and treat diabetic neuropathy and microcirculation disorders has been actively studied.Aims: The research goal was to study the dynamics of inflammatory markers, clinical manifestations of diabetic peripheral neuropathy and laser Doppler flowmetry of skin microcirculation during treatment with various doses of cholecalciferol in patient...

Tumor angiogenesis is believed to result from an imbalance of pro- and anti-angiogenic factors. Angiogenesis is an important component in the development of thyroid goitre. Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) represents a family of specific endothelial cell mitogens involved in normal angiogenesis and in tumor development. Consequently, a panel of anti-angiogenic factors was addressed in a representative sample of VEGF receptor-2 (VEGFR-...

Objective: The aim of this study was to evaluate the influence of subclinical and overt hyperthyroidism on the chosen markers of endothelial function.Material and methods: The groups studied consisted of 97 hyperthyroid subjects (51 with subclinical and 46 with overt hyperthyroidism) and 39 healthy controls matched for age, gender and body mass index. The following parameters were measured: TSH, FT3, FT4 (by MEIA), VCAM-1 (vascular cell adhesion molecule...

Incidentalomas of adrenal glands are found in approximately 0.4–4.4% of abdominal CT-scan examinations and some of them can be caused by congenital adrenal hyperplasia (CAH). Bilateral masses can be detected in 10–15% of cases. CAH is one of the most common autosomal recessively inherited disorders. Non-classical form of congenital adrenal hyperplasia (NCCAH), is the milder form of the 21-hydroxylase deficiency, with the estimated incidence of 1:1000 worldwide.<p...

Objective: There has been no consensus on the medical management of diabetes in acromegaly patients. The primary approach is like the general population, and metformin is considered first-line therapy. Sodium-glucose cotransporter inhibitors (SGLT2is) are a novel antidiabetic class which has an improving effect on insulin resistance. There is no recommendation regarding their use for diabetic acromegaly patients despite their potential beneficial effects by inducing glucosuria...

Introduction: Obesity and metabolic disturbances constitute an important health problem in elderly women. Due to the multifactorial background of these disorders, assessment of the interaction between risk factors is still a significant element of prevention and health promotion in this group. Studies have shown, inter alia, the relationship between low physical activity and vitamin D deficiency with obesity and its complications. Furthermore vitamin D influences production of...